Electrically responsive ZnO nanotubes for controlled release of biomolecules

C. C. Lin, Y. W. Chen, C. S. Hsiao, S. Y. Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

We developed a novel electro-responsive drug delivery device by depositing fluorescein isothiocyanate (FITC)-loaded zinc oxide nanotubes (ZTs) onto indium tin oxide (ITO)/polyethylene terephthalate (PET) substrates (called FITC-ZTs-ITO/PET). With a large payload of FITC up to 0.98 mmol g−1, the FITC-ZTs simultaneously provide a burst-like FITC release and a repeated step-like release after application of an electrical field at specific resonant frequencies. Additionally, FITC-ZTs-ITO/PET is biocompatible with both HeLa and MRC5 cells for ZT concentrations below 50 μg/ml. These results demonstrate that FITC-ZTs-ITO/PET is a new platform that can provide local, on-demand electrically responsive drug release for biomedical applications.

Original languageEnglish
Pages (from-to)S802-S806
JournalCeramics International
Volume43
DOIs
StatePublished - Aug 2017

Keywords

  • Drug release
  • Electrically responsive
  • Nanoresonators
  • ZnO nanotube

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