Electrical signal amplification of DNA hybridization by nanoparticles in a nanoscale gap

Chun Chi Chen*, Fu-Hsiang Ko, Chieh Tso Chen, Tzeng Feng Liu, Edward Yi Chang, Yuh-Shyong Yang, Su Jan Yan, Tieh Chi Chu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

We report two different methods to electrically sense deoxyribonucleic acid (DNA) hybridization and suggest that nanoparticles can act as hopping sites that amplify the conductance of the hybridized DNA strand. Single-stranded DNA has no amplification effect on conductance, but hybridized double-stranded DNA tethered to 10 nm gold nanoparticles exhibits a 30-fold amplification of conductance. As to the aldehyde-derived target DNA method, silver nanoparticles from silver ion reduction in the 70 nm nanogap enhance the conductance signal by 106.

Original languageEnglish
Article number253103
JournalApplied Physics Letters
Volume91
Issue number25
DOIs
StatePublished - 1 Dec 2007

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