Electrical-sensitive nanoparticle composed of chitosan and tetraethyl orthosilicate for controlled drug release

Kun Ho Liu, Ting Yu Liu, Dean-Mo LIu, San-Yuan Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

In the present study, the nanoparticles with size of 50-130 nm composed of chitosan (CS) and tetraethyl orthosilicate (TEOS), which showed electrically-controlled release profile, were prepared. Myoglobin was encapsulated into the nanoparticles with an encapsulation efficiency as high as 91.5% and a maximum loading capacity of 70.2% that can be achieved. Here, TEOS was hydrolyzed and condensed to form interpenetration network with CS. Increase of TEOS content results in a shift of the release profile from swelling-controlled towards diffusion-controlled mechanism. The "slow-to-burst" and "near-zero" release of the myoglobin can be effectively controlled by applying DC electric field between "on" and "off."

Original languageEnglish
Pages (from-to)1198-1203
Number of pages6
JournalJournal of Nanoscience and Nanotechnology
Volume9
Issue number2
DOIs
StatePublished - 1 Jan 2009

Keywords

  • Electric-stimuli
  • Nanoparticle
  • Polyelectrolyte

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