Efficacies of treatments for anti-NMDA receptor encephalitis

Hsiuying Wang*

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Treatments for anti-N-methyl-D-aspartate (NMDA) receptor encephalitis include immunotherapy with steroids, intravenous immunoglobulin, plasma exchange, or plasmapheresis as first-line treatments, immunotherapy with rituximab or cyclophosphamide as second-line treatments, and tumor removal. In this systematic review, we evaluated previous studies and examined the association between certain microRNAs and anti-NMDA receptor encephalitis to investigate the performance of different treatment combinations. The efficacies of different combinations of treatments classified into the following four categories were compared: (I) intravenous immunoglobulin administration, (II) plasmapheresis or plasma exchange, (III) treatment with rituximab or cyclophosphamide and (IV) tumor removal. Statistical analyses showed that treatment combinations including at least two of these categories resulted in higher efficacy rates than treatment with a single form of therapy. These findings suggest that if a patient is not recovering, converting to other therapies is more likely to result in early recovery than continuing on the original therapy.

Original languageEnglish
Pages (from-to)651-663
Number of pages13
JournalFrontiers in Bioscience - Landmark
Volume21
Issue number3
DOIs
StatePublished - 1 Jan 2016

Keywords

  • Anti-NMDA Receptor Encephalitis
  • Efficacy Rate
  • Treatment

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