Effects of amiodarone on wave front dynamics during ventricular fibrillation in isolated swine right ventricle

Chikaya Omichi, Shengmei Zhou, Moon Hyoung Lee, Ajay Naik, Che Ming Chang, Alan Garfinkel, James N. Weiss, Shien-Fong Lin, Hrayr S. Karagueuzian, Peng Sheng Chen*

*Corresponding author for this work

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

The effects of acute amiodarone infusion on dynamics of ventricular fibrillation (VF) are unclear. Six isolated swine right ventricles (RVs) were studied in vitro. Activation patterns during VF were mapped optically, whereas action potentials were recorded with a glass microelectrode. At base-line, VF was associated with frequent spontaneous wave breaks. Amiodarone (2.5 μg/ml) reduced spontaneous wave breaks and increased the cycle length (CL) of VF from 83.3 ± 17.8 ms at baseline to 118.4 ± 25.8 ms during infusion (P < 0.05). Amiodarone increased the reentrant wave front CL (114.4 ± 15.5 vs. 78.2 ± 19.0 ms, P < 0.05) and central core area (4.1 ± 3.8 vs. 0.9 ± 0.3 mm 2, P < 0.05). Within 30 min of infusion, VF terminated (n = 1), converted to ventricular tachycardia (VT) (n = 1) or continued at a slower rate (n = 4). Amiodarone flattened the APD restitution curves. We conclude that amiodarone reduced spontaneous wave breaks. It might terminate VF or convert VF to VT. These effects were associated with the flattening of APD restitution slope and increased core size of reentrant wave fronts.

Original languageEnglish
Pages (from-to)H1063-H1070
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume282
Issue number3 51-3
DOIs
StatePublished - 29 Jun 2002

Keywords

  • Action potential duration restitution
  • Antiarrhythmic agents
  • Optical mapping
  • Pharmacology
  • Sudden death

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