Effect of hydroxyapatite nanoparticles on ibuprofen release from carboxymethyl-hexanoyl chitosan/O-hexanoyl chitosan hydroger

Tse Ying Liu, Ting Yu Liu, San-Yuan Chen*, Shian Chuan Chen, Dean-Mo LIu

*Corresponding author for this work

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

In order to explore the effect of nanofiller on the regulation of the drug release behavior from microsphere-embedded hydrogel prepared by carboxymethyl-hexanoyl chitosan (HNOCC) and O-hexanoyl chitosan (OHC), the release kinetics was investigated in terms of various amounts of calcium-deficient hydroxyapatite (CDHA) nanoparticles incorporated. HNOCC is a novel chitosan-based hydrophilic matrix with a burst release profile in a highly swollen state. The drug release kinetics of the HNOCC hydrogel can be regulated by incorporation of well-dispersed CDHA nanoparticles. It was found that the release duration of ibuprofen (IBU) from HNOCC was prolonged with increasing amounts of CDHA which acts as a crosslink agent and diffusion barrier. On the contrary, the release duration of the IBU from OHC (hydrophobic phase) was shortened through increasing the CDHA amount over 5%, which is due to the hydrophilic nature of the CDHA nanoparticles destroying the intermolecular hydrophobic interaction and accelerating OHC degradation. Thus, water accessibility and molecular relaxation were enhanced, resulting in a higher release rate. In addition, sustained and sequential release behavior was achieved by embedding the OHC microspheres (hydrophobic phase) into the HNOCC (hydrophilic phase) matrix, which could significantly prolong the release duration of the HNOCC drug-loaded implant.

Original languageEnglish
Pages (from-to)2929-2935
Number of pages7
JournalJournal of Nanoscience and Nanotechnology
Volume6
Issue number9-10
DOIs
StatePublished - 1 Sep 2006

Keywords

  • Amphiphilic Hydrogel
  • Carboxymethyl-Hexanoyl Chitosan
  • Cytotoxicity
  • Drug Release
  • Hydrogel-Based Implant
  • O-Hexanoyl Chitosan

Fingerprint Dive into the research topics of 'Effect of hydroxyapatite nanoparticles on ibuprofen release from carboxymethyl-hexanoyl chitosan/O-hexanoyl chitosan hydroger'. Together they form a unique fingerprint.

  • Cite this