Various CaO/ZrO 2 as sintering sample was reacted with titanium at 1400°C/3hr in argon. Investigation CaZrO 3 content can be effective to control the interfacial reaction. The microstructure of the reaction interface was characterized using x-ray diffraction (XRD) and scanning electron microscopy (SEM/EDS). The reaction of ceramic side tends to produce CaZrO 3 between Ti and 35 mol% CaO/ZrO 2 at 1400°. When zirconium atoms and oxygen atoms simultaneously diffusion to the titanium side. The zirconium atoms will slow down the oxygen atoms diffusion into the titanium side. Prevention the phase formation among titanium side and ceramic side not to be fast. According to the results, the 35 mol% CaO/ZrO 2 will be effective than the other components to generate CaZrO 3. The more amount of the CaZrO 3, the more effectively block titanium atoms, zirconium atoms and oxygen atoms interdiffusion.