ECG gated ultrasonic small animal imaging

Jian Hung Liu*, Geng Shi Jeng, Tung Ke Wu, Pai Chi Li

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

Echocardiography is a routine clinical procedure to diagnose cardiac functions. The organic structure of the mouse is similar to that of human so that murine echocardiography has potentially become an effective tool for the assessment of human cardiovascular disease. However, clinical ultrasonic imaging systems are not suitable for murine cardiac imaging due to its limited spatial and temporal resolution. Thus, high frequency ultrasonic imaging (≥ 20 MHz) is necessary in order to provide spatial resolution at the order of 100 μm. Furthermore, due to the lack of transducer arrays at such a high frequency, single-element transducer with mechanical scanning is typically used. Thus the frame rate is insufficient for imaging the quick motion of the mouse. In this paper, a high frequency ultrasonic imaging system with electrocardiography gating is built in order to provide both high spatial resolution and high temporal effecting resolution. The system utilizes the R-wave trigger signal from murine electrocardiography. Image data are acquired in either the block scanning mode or the line scanning mode. In block scanning, murine cardiac images in systole and diastole can be retrospectively reconstructed with a short data acquisition time. In line scanning, on the other hand, images during the entire cardiac cycle can be obtained. It is demonstrated that the effective frame rate can be up to 2 kHz, which is only limited by the pulse repetition rate of the system.

Original languageEnglish
Title of host publicationProceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
Pages1762-1765
Number of pages4
StatePublished - 2005
Event2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 - Shanghai, China
Duration: 1 Sep 20054 Sep 2005

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume7 VOLS
ISSN (Print)0589-1019

Conference

Conference2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
CountryChina
CityShanghai
Period1/09/054/09/05

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