Dynamics and mechanism of DNA repair in a biomimetic system: Flavin-thymine dimer adduct

Ya-Ting Kao, Qin Hua Song, Chaitanya Saxena, Lijuan Wang, Dongping Zhong*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

To mimic photolyase for efficient repair of UV-damaged DNA, numerous biomimetic systems have been synthesized, but all show low repair efficiency. The molecular mechanism of this low-efficiency process is still poorly understood. Here we report our direct mapping of the repair processes of a flavin-thymine dimer adduct with femtosecond resolution. We followed the entire dynamic evolution and observed direct electron transfer (ET) from the excited flavin to the thymine dimer in 79 ps. We further observed two competitive pathways, productive dimer ring splitting within 435 ps and futile back-ET in 95 ps. Our observations reveal that the underlying mechanism for the low repair quantum yield of flavin-thymine dimer adducts is the short-lived excited flavin moiety and the fast dynamics of futile back-ET without repair.

Original languageEnglish
Pages (from-to)1501-1503
Number of pages3
JournalJournal of the American Chemical Society
Volume134
Issue number3
DOIs
StatePublished - 25 Jan 2012

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