Dynamic contrast-enhanced magnetic resonance angiography of Gd-TTDA-BOM and Gd-DTPA at 3T in a normal rat model

Jo Chi Jao, Yen Ku Chen, Twei Shiun Jaw, Yun-Ming Wang, Po Chou Chen*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Gd-TTDA-BOM is designed to be a paramagnetic contrast agent for magnetic resonance imaging (MRI). The ligand TTDA-BOM includes a benzyloxymethyl group to raise the lipophilicity. It is known that Gd-TTDA-BOM has faster water exchange rate and higher reorientational time than Gd-DTPA. It also has high bound relaxivity with human serum albumin (HSA). This study first evaluated the relaxivity values of Gd-TTDA-BOM and Gd-DTPA solutions with 4.5% HSA and then investigated the signal enhancement of dynamic contrast-enhanced magnetic resonance angiography after Gd-TTDA-BOM or Gd-DTPA bolus injection in a normal rat model. A 3T whole-body MR scanner providing higher signal to noise ratios (SNR) than 1.5T was used. The results showed that Gd-TTDA-BOM with HSA had higher relaxivity values than Gd-DTPA with HSA. Gd-TTDA-BOM also caused higher and longer signal enhancement in aorta than Gd-DTPA. It is concluded that Gd-TTDA-BOM has a good potential to be a blood pool MRI contrast agent.

Original languageEnglish
Title of host publicationProceedings - 2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012
Pages781-783
Number of pages3
DOIs
StatePublished - 1 Oct 2012
Event2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012 - Macau, China
Duration: 28 May 201230 May 2012

Publication series

NameProceedings - 2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012

Conference

Conference2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012
CountryChina
CityMacau
Period28/05/1230/05/12

Keywords

  • 3T
  • contrast agents
  • Gd-DTPA
  • Gd-TTDA-BOM
  • magnetic resonance angiography
  • rat

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