Drug screening lobule-mimetic liver chip for studying interleukin 8 response in K. pneumonia infected hepatocytes

Ya Ju Chu, Zhe Chong Wang, Shih Mo Yang, Hwei-Ling Peng, Cheng Hsien Liu

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

We report an integrated platform which integrates a lobule mimetic liver chip to study the pyogenic hepatic abscess model with a gradient generator for monitoring the IL-8 response. Taking a step forward towards providing targeted medicine, this platform is capable of screening the efficacy of antioxidants. The drug screening platform integrates a continuous concentration gradient generator combined with acoustic mixer and an in vitro lobule mimetic liver model. The gradient generator allows simultaneous administration of drug dose at different concentration to the infected hepatoma cells which helps us to monitor the in vitro dose-dependent TMTU response.

Original languageEnglish
Title of host publication15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Pages1352-1354
Number of pages3
StatePublished - 1 Dec 2011
Event15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States
Duration: 2 Oct 20116 Oct 2011

Publication series

Name15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Volume2

Conference

Conference15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
CountryUnited States
CitySeattle, WA
Period2/10/116/10/11

Keywords

  • Acoustic micromixer
  • Cell patterning
  • Drug screening
  • Gradient
  • Pyogenic hepatic abscess model

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