Droplet Size-Aware High-Level Synthesis for Micro-Electrode-Dot-Array Digital Microfluidic Biochips

Zipeng Li, Kelvin Yi Tse Lai, Po Hsien Yu, Krishnendu Chakrabarty, Tsung Yi Ho, Chen-Yi Lee

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


A digital microfluidic biochip (DMFB) is an attractive technology platform for automating laboratory procedures in biochemistry. In recent years, DMFBs based on a microelectrode-dot-array (MEDA) architecture have been demonstrated. However, due to the inherent differences between today's DMFBs and MEDA, existing synthesis solutions for biochemistry mapping cannot be utilized for MEDA biochips. We present the first synthesis approach that can be used for MEDA biochips. We first present a general analytical model for droplet velocity and validate it experimentally using a fabricated MEDA biochip. We then present the proposed synthesis method targeting reservoir placement, operation scheduling, module placement, routing of droplets of various sizes, and diagonal movement of droplets in a two-dimensional array. Simulation results using benchmarks and experimental results using a fabricated MEDA biochip demonstrate the effectiveness of the proposed synthesis technique.

Original languageEnglish
Article number7883927
Pages (from-to)612-626
Number of pages15
JournalIEEE Transactions on Biomedical Circuits and Systems
Issue number3
StatePublished - 1 Jun 2017


  • Digital microfluidics
  • high-level synthesis
  • lab-on-chip
  • micro-electrode-dot-array (MEDA)
  • optimization algorithm

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