Double michael addition reactions of the Nazarov reagent with 2-cyano-2-cycloalkenones: An alternative approach to cis -fused bicyclic systems

Che Hao Tu, Yen-Ku Wu, Kak Shan Shia, Sheng Chu Kuo, Hsing Jang Liu*, Min Tsang Hsieh

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

A highly stereoselective annulation reaction of 2-cyano-2-cycloalkenones with the Nazarov reagent catalyzed by 1,8-diazaÂbicyclo[5.4.0]undec-7-ene (DBU), leading to densely functionalized bicyclic systems, is developed.

Original languageEnglish
Article numberST-2013-W0929-L
Pages (from-to)543-546
Number of pages4
JournalSynlett
Volume25
Issue number4
DOIs
StatePublished - 1 Mar 2014

Keywords

  • α-cyano enones
  • annulation
  • bicyclic compounds
  • double Michael addition
  • Nazarov reagent

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