Divergent ionic liquid supported synthesis of isolable guanidine linked quinoxalinone and benzodiamine

Li Hsun Chen, Zhan Hui Xu, Chun Chung Lin, Chung-Ming Sun*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Ionic liquid supported synthesis of guanidine linked piperazine, diazepane, and aminomethylpiperidine to difluoroquinoxalinones and difluoro benzodiamine was achieved by two regioisomeric products. They were isolated from one pot reduction and intramolecular cyclization to afford quinoxalinone ring system with traceless cleavage of ionic liquid support. Besides, the ionic-supported other isomer was further cleaved in methanol. All the reactions were carried out on an ionic liquid support under various conditions to deliver biologically relevant scaffolds with high purity and excellent yields.

Original languageEnglish
Pages (from-to)454-458
Number of pages5
JournalTetrahedron Letters
Volume54
Issue number6
DOIs
StatePublished - 6 Feb 2013

Keywords

  • Ionic liquid support
  • Microwave synthesis
  • One-Bead-Two-Compound
  • Quinoxalinones

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