For enhancing spectrum efficiency, in-band full-duplex technology is one of the candidate technical solution. But, self-interference (SI) signal causes dramatically degrade the performance. In practically, memory effect which cause harmonic in amplifier will be hard to be estimated. Therefore, we utilizes the dynamic regression (DR) to implement digital interference cancellation (DIC) for mitigate the memory effect. Two platforms are constructed to evaluate this mechanism. In both platforms, the SI signal could effectively reduction and the residual signal could be attenuated close to noise floor. In software-defined radio (SDR) platform also proves that the proposed dynamic regression based DIC (DRDIC) is sufficient to attenuate the SI signal, where successfully perform video streaming demonstration.