Diffuser-aided time-domain diffuse optical imaging: A phantom study

Chia-Wei Sun*, Ching-Cheng Chuang, Chia Yen Lee, Chung Ming Chen

*Corresponding author for this work

Research output: Contribution to journalArticle


We present the first experimental results of time-resolved diffuser-aided diffuse optical imaging (DADOI) method in this paper. A self-manufactured diffuser plate was inserted between the optode and the surface of a scattering medium. The diffuser was utilized to enhance the multiple scattering that destroys the image information for baseline measurement of turbid medium. Therefore, the abnormality can be detected with the modified optical density calculation. The time-domain DADOI method can provide better imaging contrast and simpler imaging than the conventional diffuse optical tomography measurement. Besides, it also reveals rich depth information with temporal responses. Therefore, the DADOI offers a great potential to detect the breast tumor and chemotherapy monitoring in clinical diagnosis.

Original languageEnglish
Article number046008
JournalJournal of Biomedical Optics
Issue number4
StatePublished - 1 Jan 2014


  • breast tumor imaging
  • diffuse optical tomography
  • diffuser-aided diffuse optical imaging
  • near-infrared spectroscopy
  • photon migration

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