Diffuser-aided diffuse optical imaging for breast tumor: A feasibility study based on time-resolved three-dimensional Monte Carlo modeling

Ching-Cheng Chuang*, Chia Yen Lee, Chung Ming Chen, Yao Sheng Hsieh, Tsan Chi Liu, Chia-Wei Sun

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

This study proposed diffuser-aided diffuse optical imaging (DADOI) as a new approach to improve the performance of the conventional diffuse optical tomography (DOT) approach for breast imaging. The 3-D breast model for Monte Carlo simulation is remodeled from clinical MRI image. The modified Beer-Lamberts law is adopted with the DADOI approach to substitute the complex algorithms of inverse problem for mapping of spatial distribution, and the depth information is obtained based on the time-of-flight estimation. The simulation results demonstrate that the time-resolved Monte Carlo method can be capable of performing source-detector separations analysis. The dynamics of photon migration with various source-detector separations are analyzed for the characterization of breast tissue and estimation of optode arrangement. The source-detector separations should be less than 4 cm for breast imaging in DOT system. Meanwhile, the feasibility of DADOI was manifested in this study. In the results, DADOI approach can provide better imaging contrast and faster imaging than conventional DOT measurement. The DADOI approach possesses great potential to detect the breast tumor in early stage and chemotherapy monitoring that implies a good feasibility for clinical application.

Original languageEnglish
Article number6162966
Pages (from-to)1454-1461
Number of pages8
JournalIEEE Transactions on Biomedical Engineering
Volume59
Issue number5
DOIs
StatePublished - 1 May 2012

Keywords

  • Breast tumor imaging
  • Monte Carlo simulation
  • diffuse optical tomography (DOT)
  • diffuser-aided diffuse optical imaging (DADOI)
  • near-IR spectroscopy
  • photon migration

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