Differences in cardiac activation times for endocardium and epicardium in response to external electric shock

A. M. Pitruzzello*, M. C. Woods, J. P. Wikswo, Shien-Fong Lin

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Externally applied electric shocks, Ea, which are used to terminate cardiac defibrillation, operate by altering the cardiac transmembrane potential through a mechanism that is not yet understood. The effect of Ea on endocardium and epicardium was studied on Langendorff-perfused, di-4-ANEPPS stained isolated rabbit right ventricles (RV) to which a 10-40 V/cm Ea was applied from plate electrodes inside a Tyrode's bath. Field stimulation of the flat RV preparation caused immediate distributed depolarization followed by rapid, non-propagative activation of the entire RV wall. For every Ea strength tested, the activation time, Ta, of the epicardium was shorter than epicardial Ta. This difference in Ta may be attributed to a higher degree of anatomical heterogeneities on the endocardial surface.

Original languageEnglish
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PublisherIEEE
Pages286
Number of pages1
ISBN (Print)0780356756
DOIs
StatePublished - 1 Dec 1999
EventProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
Duration: 13 Oct 199916 Oct 1999

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume1
ISSN (Print)0589-1019

Conference

ConferenceProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
CityAtlanta, GA, USA
Period13/10/9916/10/99

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  • Cite this

    Pitruzzello, A. M., Woods, M. C., Wikswo, J. P., & Lin, S-F. (1999). Differences in cardiac activation times for endocardium and epicardium in response to external electric shock. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (pp. 286). (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings; Vol. 1). IEEE. https://doi.org/10.1109/IEMBS.1999.802360