Cooling is a potential treatment for induced epilepsy. There is no electric current pass through the organization of brain because it will damage it with high temperature. EEG electrodes and thermal electric (TE) coolers were integrated and placed in the head of rat. EEG electrodes were used to measure brain waveform and TE cooler was employed to be a cooling actuator to decrease temperature on the surface of cortex. Brain cortex can be cooled down lower than body temperature in order to suppress epilepsy and variance of temperature do not exceed over ± 2 °C. The experiment for suppressing epilepsy was implemented and brain waveforms of induced epilepsy were detected. Suppression with focal cooling is the main technology for the current study. We are currently determining the efficacy for the therapy of certain focal epilepsies.