Development of a multisite, closed-loop neuromodulator for the theranosis of neural degenerative diseases

Hsin Chen, Yen Chung Chang, Shih Rung Yeh, Chih Cheng Hsieh, Kea Tiong Tang, Ping Hsuan Hsieh, Yu-Te Liao, Ramesh Perumel, Ji Feng Chuang, Ching Chih Chang, Yu Chieh Chen, Shih Hsin Chen, Sung En Hsieh, Yen Peng Chen, Ye Ting Chen, Tzu Hao Liu, Yu Ming Chang, Wei Chih Lai, Chuang Yi Wu, Yu Hsin ChenYi Chin Weng

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Stimulating specific brain regions has been found useful for treating neural disorders, such as the Parkinson's disease, epilepsy, depression, etc. However, how electrical stimulation modulates neural activities remains not fully understood. As animal models provide the advantage of recording and stimulating different disease-related regions simultaneously, this paper introduces the latest development of a multisite, closed-loop-controlled microsystem for investigating novel treatments on neural degenerative diseases with freely-moving rats. The algorithms for recognizing pathological neural activities automatically are also developed and realized in hardware, so as to control the stimulation in a closed loop and in real time. The pilot studies on the efficacy of treating the Parkinson's disease with closed-loop-controlled stimulation will be presented and discussed. Finally, the feasibility of modelling and probing how neural dynamics and connectivity are modulated by stimulation will be an important topic for future research.

Original languageEnglish
Title of host publication2018 IEEE Symposium on VLSI Technology, VLSI Technology 2018
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages37-38
Number of pages2
ISBN (Electronic)9781538642160
DOIs
StatePublished - 25 Oct 2018
Event38th IEEE Symposium on VLSI Technology, VLSI Technology 2018 - Honolulu, United States
Duration: 18 Jun 201822 Jun 2018

Publication series

NameDigest of Technical Papers - Symposium on VLSI Technology
Volume2018-June
ISSN (Print)0743-1562

Conference

Conference38th IEEE Symposium on VLSI Technology, VLSI Technology 2018
CountryUnited States
CityHonolulu
Period18/06/1822/06/18

Keywords

  • Closed-loop control
  • Implantable microsystem
  • Multisite
  • Neural disorders
  • Neuromodulation

Fingerprint Dive into the research topics of 'Development of a multisite, closed-loop neuromodulator for the theranosis of neural degenerative diseases'. Together they form a unique fingerprint.

Cite this