Since the existence of nanoparticles in our environment has already attracted considerable attention due to their possible toxic impact on biological systems, the field detection of nanoparticles is becoming a technology that will be much in need. We have constructed a piezoelectric sensor with an antibody-coated electrode. The antiserum can bind gold nanoparticles with a high degree of selectivity and sensitivity. The biosensor thus constructed can detect 4, 5, or 6 nm gold nanoparticles (GNPs) depending on the coated antiserum. The sensitivity for the detection of 5 nm GNPs was 10.3 +/- 0.9 ng Hz(-1), with the low limit of detection at 5.5 ng. A quartz crystal microbalance (QCM) sensor was capable of detecting GNPs and other types of nanoparticle, such as ZnO, or Fe3O4. The current study provides, for the first time, a platform for detecting nanoparticles in a convenient, economical manner.
- STOKES-RAMAN SCATTERING; IN-VIVO; PARTICLE-SIZE; SURFACE-CHEMISTRY; COLLOIDAL GOLD; TOXICITY; BIODISTRIBUTION; DOPAMINE; NANORODS; GENE