Detecting small lung tumors in mouse models by refractive-index microradiology

Chia Chi Chien, Guilin Zhang*, Y. Hwu, Ping Liu, Weisheng Yue, Jianqi Sun, Yan Li, Hongjie Xue, Lisa X. Xu, Chang Hai Wang, Nanyow Chen, Chien Hung Lu, Ting Kuo Lee, Yuh Cheng Yang, Yen Ta Lu, Yu-Tai Ching, T. F. Shih, P. C. Yang, J. H. Je, G. Margaritondo

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Refractive-index (phase-contrast) radiology was able to detect lung tumors less than 1 mm in live mice. Significant micromorphology differences were observed in the microradiographs between normal, inflamed, and lung cancer tissues. This was made possible by the high phase contrast and by the fast image taking that reduces the motion blur. The detection of cancer and inflammation areas by phase contrast microradiology and microtomography was validated by bioluminescence and histopathological analysis. The smallest tumor detected is less than 1 mm 3 with accuracy better than 1∈×∈10 -3 mm 3 . This level of performance is currently suitable for animal studies, while further developments are required for clinical application. [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)827-835
Number of pages9
JournalAnalytical and Bioanalytical Chemistry
Issue number3
StatePublished - 1 Aug 2011


  • Lung cancer
  • Real-time imaging
  • Synchrotron X-ray imaging

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