Design and synthesis of activity probes for glycosidases

Charng Sheng Tsai, Yaw-Kuen Li, Lee Chiang Lo*

*Corresponding author for this work

Research output: Contribution to journalArticle

73 Scopus citations


(graph presented) A new synthetic route was developed for the preparation of activity probe 1 for β-glucosidase in this study. The key glycosidation step begins with benzyl p-hydroxyphenylacetate. Benzylic functionalization for the construction of the trapping device was achieved at later stages. Probe 1 was shown to be able to label the target enzyme. This cassette-like design offers great flexibility for future alterations. It would allow the synthetic scheme to expand to other glycosidase probes with different linker/reporter combinations.

Original languageEnglish
Pages (from-to)3607-3610
Number of pages4
JournalOrganic Letters
Issue number21
StatePublished - 17 Oct 2002

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