An anti-glare luminaire design is proposed to reduce the effect of glare and the multi-shadow while preserving high optical efficiency, high illumination uniformity and low unified glare rating (UGR). Comparison to the traditional direct light emitting diode (LED) luminaire in optical simulations showed an enhancement of the illumination uniformity from 64.9% to 80.0%. The optical efficiency was 79.5%, and the UGR value was controlled under 18.8. For the actual measurement, the finished product had an illumination uniformity of 77.0%, optical efficiency of 76.0%, UGR value of 19.0, and efficacy of 81.4 lm/w. Through this design, the lighting performance was greatly enhanced.