Decrease in plasma cyclophilin a concentration at 1 month after myocardial infarction predicts better left ventricular performance and synchronicity at 6 months: A pilot study in patients with ST elevation myocardial infarction

Ching Hui Huang, Chia Chu Chang, Chen Ling Kuo, Ching Shan Huang, Chih-Sheng Lin, Chin San Liu*

*Corresponding author for this work

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Background: Cyclophilin A (CyPA) concentration increases in acute coronary syndrome. In an animal model of acute myocardial infarction, administration of angiotensin-converting-enzyme inhibitor was associated with lower left ventricular (LV) CyPA concentration and improved LV performance. This study investigated the relationships between changes in plasma CyPA concentrations and LV remodeling in patients with ST-elevation myocardial infarction (STEMI).

Methods and Results: We enrolled 55 patients who underwent percutaneous coronary intervention for acute STEMI. Plasma CyPA, matrix metalloproteinase (MMP), interleukin-6 and high-sensitivity C-reactive protein concentrations were measured at baseline and at one-month follow-up. Echocardiography was performed at baseline and at one-, three-, and six-month follow-up. Patients with a decrease in baseline CyPA concentration at one-month follow-up (n = 28) had a significant increase in LV ejection fraction (LVEF) (from 60.2 ± 11.5% to 64.6 ± 9.9%, p < 0. 001) and preserved LV synchrony at six months. Patients without a decrease in CyPA concentration at one month (n = 27) did not show improvement in LVEF and had a significantly increased systolic dyssynchrony index (SDI) (from 1.170 ± 0.510% to 1.637 ± 1.299%, p = 0.042) at six months. Multiple linear regression analysis showed a significant association between one-month CyPA concentration and six-month LVEF. The one-month MMP-2 concentration was positively correlated with one-month CyPA concentration and LV SDI.

Conclusions: Decreased CyPA concentration at one-month follow-up after STEMI was associated with better LVEF and SDI at six months. Changes in CyPA, therefore, may be a prognosticator of patient outcome.

Original languageEnglish
Pages (from-to)38-47
Number of pages10
JournalInternational journal of biological sciences
Volume11
Issue number1
DOIs
StatePublished - 1 Jan 2015

Keywords

  • Acute myocardial infarction
  • Cyclophilin A
  • Left ventricular dyssynchrony
  • Left ventricular ejection fraction
  • Matrix metalloproteinase

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