Curiosity-driven research on acyl radicals

Ilhyong Ryu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

With a strong desire to develop radical carbonylation chemistry, we naturally focused our attention on the key reactive intermediate, the acyl radical. Acyl radicals have been regarded as nucleophilic radicals towards electron-poor alkenes, akin to vinyl radicals. However, deeming that acyl radicals may act as pseudo-carbonyl compounds, we observed acyl radicals to behave as electrophilic species, very unlike vinyl radicals. This essay is a personal account of the area of acyl radical chemistry.

Original languageEnglish
Pages (from-to)826-831
Number of pages6
JournalYuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
Volume74
Issue number8
DOIs
StatePublished - 1 Jan 2016

Keywords

  • Acyl radical
  • Acyl radical cyclization
  • Amide
  • Amidine
  • Amine
  • Aminocarbonylation
  • Carbon monoxide
  • Dual orbital effect
  • Enyne
  • Imine
  • Lactam
  • Polarity-matched cyclization
  • [2+2+1] reaction

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