CPSARST: An efficient circular permutation search tool applied to the detection of novel protein structural relationships

Wei-Cheng Lo, Ping Chiang Lyu*

*Corresponding author for this work

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Circular permutation of a protein can be visualized as if the original amino- and carboxyl termini were linked and new ones created elsewhere. It has been well-documented that circular permutants usually retain native structures and biological functions. Here we report CPSARST (Circular Permutation Search Aided by Ramachandran Sequential Transformation) to be an efficient database search tool. In this post-genomics era, when the amount of protein structural data is increasing exponentially, it provides a new way to rapidly detect novel relationships among proteins.

Original languageEnglish
Article numberR11
JournalGenome Biology
Volume9
Issue number1
DOIs
StatePublished - 18 Jan 2008

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