Cph1p negatively regulates MDR1 involved in drug resistance in Candida albicans

Hsiu Jung Lo, Kuo-Yun Tseng, Yeong-Yi Kao, Ming-Yang Tsao, Han-Lun Lo, Yun-Liang Yang

Research output: Contribution to journalArticle

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Abstract

The cph1/cph1 efg1/efg1 double mutant in Candida albicans is defective in filamentous growth and is avirulent in a mouse model. We previously reported that Efg1p but not Cph1p is involved in drug resistance by negatively regulating ERG3 in C. albicans. In the current study, we have found that overexpression of 0411 in Saccharomyces cerevisiae increases susceptibility to the antifungal drug fluconazole. Furthermore, in C. albicans, null mutation of 0411 increased the expression of MDR1 as well as decreased susceptibility to fluconazole and voriconazole but not to amphotericin B. These findings indicate that although Efg1p and Cph1p may have the same effects on virulence, they have opposite effects on drug resistance in C. albicans. (C) 2015 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
Original languageEnglish
Pages (from-to)617-621
Number of pages5
JournalInternational Journal of Antimicrobial Agents
DOIs
StatePublished - Jun 2015

Keywords

  • Candida albicans; Drug resistance; Efflux pump; Virulence factor; Regulation
  • HUMAN-IMMUNODEFICIENCY-VIRUS; MULTIDRUG-RESISTANCE; ANTIFUNGAL AGENTS; EFFLUX PUMP; CDR1; FLUCONAZOLE; CONTRIBUTE; GENE; CEREVISIAE; EXPRESSION

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