Coupling-Reagent-Free Synthesis of Dipeptides and Tripeptides Using Amino Acid Ionic Liquids

Shinya Furukawa*, Takahide Fukuyama, Akihiro Matsui, Mai Kuratsu, Ryotaro Nakaya, Takashi Ineyama, Hiroshi Ueda, Ilhyong Ryu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


A general method for the synthesis of dipeptides has been developed, which does not require any coupling reagents. This method is based on the reaction of readily available HCl salts of amino acid methyl esters with tetrabutylphosphonium amino acid ionic liquids. The isolation procedure of stepwise treatment with AcOH is easy to carry out. The method was extended to the synthesis of tripeptide, tyrosyl-glycyl-glycine, present in IMREG-1, also.

Original languageEnglish
Pages (from-to)11980-11983
Number of pages4
JournalChemistry - A European Journal
Issue number34
StatePublished - 1 Aug 2015


  • amino acid ionic liquids
  • coupling-reagent free
  • dipeptides
  • tripeptides

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