Correction of motion artifact in cardiac optical mapping using image registration

Gustavo K. Rohde*, Benoit M. Dawant, Shien-Fong Lin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Cardiac motion is one of the main sources of artifacts in epifluorescence imaging experiments. It can cause significant error in electrophysiological measurements such as action potential duration. We present a novel approach that uses image registration based on maximization of mutual information to correct for in-plane cardiac motion in such experiments. The approach is relatively fast (a few seconds per frame) and is performed entirely post acquisition. The image registration approach is an alternative to traditional approaches such as mechanical restraint of the heart or addition of chemical uncouplers. Our results show that the image registration method significantly reduces motion-related artifacts in experimental data.

Original languageEnglish
Pages (from-to)338-341
Number of pages4
JournalIEEE Transactions on Biomedical Engineering
Issue number2
StatePublished - 1 Feb 2005


  • Image registration
  • Motion correction
  • Mutual information
  • Optical mapping

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