Core-shell nanocapsules stabilized by single-component polymer and nanoparticles for magneto-chemotherapy/hyperthermia with multiple drugs

Shang Hsiu Hu, Bang Jie Liao, Chin Sheng Chiang, Po Jung Chen, I. Wei Chen, San-Yuan Chen*

*Corresponding author for this work

Research output: Contribution to journalArticle

97 Scopus citations

Abstract

Iron-oxide-containing double emulsion capsules carrying both hydrophilic and hydrophobic therapeutic molecules can deliver drugs and energy on demand in vivo. Magneto-chemotherapy/hyperthermia involves a burst-like release of hydrophilic doxorubicin and hydrophobic paclitaxel, remotely triggered by a high frequency magnetic field, which also releases energy via internalized iron oxide nanoparticles, all contributing to cell kill.

Original languageEnglish
Pages (from-to)3627-3632
Number of pages6
JournalAdvanced Materials
Volume24
Issue number27
DOIs
StatePublished - 17 Jul 2012

Keywords

  • double emulsions
  • hyperthermia
  • iron oxide nanoparticles
  • nanocapsules
  • synergic therapy

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