Global synchronization in complex networks has attracted considerable interest in various fields. There are mainly two analytical approaches for studying such time-varying networks. The first approach is Lyapunov function-based methods. For such an approach, the connected-graph-stability (CGS) method arguably gives the best results. Nevertheless, CGS is limited to the networks with cooperative couplings. The matrix measure approach (MMA) proposed by Chen, although having a wider range of applications in the network topologies than that of CGS, works for smaller numbers of nodes in most network topologies. The approach also has a limitation with networks having partial-state coupling. Other than giving yet another MMA, we introduce a new and, in some cases, optimal coordinate transformation to study such networks. Our approach fixes all the drawbacks of CGS and MMA. In addition, by merely checking the structure of the vector field of the individual oscillator, we shall be able to determine if the system is globally synchronized. In summary, our results can be applied to rather general time-varying networks with a large number of nodes.