Cooling stimulation on cerebral cortex for epilepsy suppression with integration of micro-invasive electrodes and TE coolers

Jin-Chern Chiou, Lei Chun Chou, Shang Wei Tsai*, Kuan Chou Hou, Chih Wei Chang

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Epilepsy suppression with cooling stimulation is the primary purpose for this study. In this dissertation, cooling stimulation was implemented and demonstrated on cerebral cortex of rats. Electrodes with needle structure was designed and fabricated by using MEMS technology to minimize the size of device. A TE cooler was used to create cooling source and it can be control via electrical current. A cooler component was integrated with an electrode and a TE cooler, in addition, a thermal sensor was also combined with it to detect temperature variation, which was affected by cooling cerebral cortex. The cooler components were implanted on surface of cerebral with deep brain stimulation and the thermal sensors were penetrated into cortex to measure temperature variation which can verify the functions of cooler components. In our experimental results, electrodes with needle structure can improve efficiency of epilepsy suppression due to the particular structure. Duration, frequency and average single time of epileptic waveforms were used to identify to performance of suppression.

Original languageEnglish
Title of host publication8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013
Pages1249-1252
Number of pages4
DOIs
StatePublished - 2 Sep 2013
Event8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013 - Suzhou, China
Duration: 7 Apr 201310 Apr 2013

Publication series

Name8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013

Conference

Conference8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013
CountryChina
CitySuzhou
Period7/04/1310/04/13

Keywords

  • epilepsy
  • MEMS
  • needle electrode
  • TE cooler

Fingerprint Dive into the research topics of 'Cooling stimulation on cerebral cortex for epilepsy suppression with integration of micro-invasive electrodes and TE coolers'. Together they form a unique fingerprint.

  • Cite this

    Chiou, J-C., Chou, L. C., Tsai, S. W., Hou, K. C., & Chang, C. W. (2013). Cooling stimulation on cerebral cortex for epilepsy suppression with integration of micro-invasive electrodes and TE coolers. In 8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013 (pp. 1249-1252). [6559945] (8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013). https://doi.org/10.1109/NEMS.2013.6559945