Controlled pulsatile drug release from a ferrogel by a high-frequency magnetic field

Shang Hsiu Hu, Ting Yu Liu, Dean-Mo LIu*, San-Yuan Chen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

114 Scopus citations

Abstract

A high-frequency magnetic field (HFMF) triggered pulsatile drug delivery ferrogel with a mechanically reliable and flexible hybrid structure composed of gelatin and magnetic nanoparticles (nanomagnets) were studied. A highly controllable and repeatable burst release with desirable precision from the ferrogels under cyclic exposures to the high-frequency magnetic stimuli were also analyzed. The nanomagnets were essentially chemically bounded with the gelatin matrix to form the ferrogel, which further evidenced from XPS analysis. The higher binding energy was believed to be a result of esterification between hydroxide moiety on the surface of the MNPs and carboxylic acid group of gelatin, indicating an excellent chemical affinity between both participating phases and a strong solid network of the ferrogels. One clinically important advantage of this high-frequency-modulated fast-acting drug delivery ferrogel is that it can potentially meet immediate urgent physiological needs.

Original languageEnglish
Pages (from-to)6786-6788
Number of pages3
JournalMacromolecules
Volume40
Issue number19
DOIs
StatePublished - 18 Sep 2007

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