Continuous microflow synthesis of butyl cinnamate by a Mizoroki-Heck reaction using a low-viscosity ionic liquid as the recycling reaction medium

Shifang Liu, Takahide Fukuyama, Masaaki Sato, Ilhyong Ryu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

121 Scopus citations

Abstract

A continuous microflow system was developed with efficient catalyst recycling for a Mizoroki-Heck reaction of iodobenzene with butyl acrylate, using a low-viscosity ionic liquid ([bmim]-NTf2) as the reaction medium. Using a CPC CYTOS Lab System as the microreaction apparatus, in combination with an originally developed microextraction/catalyst recycling system, the reaction medium, which contained Pd catalyst could be continuously recycled to provide a total of 115.3 g (80%, 10 g/h) of the desired product.

Original languageEnglish
Pages (from-to)477-481
Number of pages5
JournalOrganic Process Research and Development
Volume8
Issue number3
DOIs
StatePublished - 1 May 2004

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