Computation of brain neurodegeneration in the Alzheimer's fly

P. C. Lee; Y. R. Huang; H. M. Chang; A. S. Chiang; Yu-Tai Ching

doi:10.1117/12.653069

Computation of brain neurodegeneration in the Alzheimer's fly

P. C. Lee^*, Y. R. Huang, H. M. Chang, A. S. Chiang, Yu-Tai Ching

^*Corresponding author for this work

Department of Computer Science

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Expression of human A/342 peptide in the Drosophila brain induces pathological phenotypes resembling Alzheimer's disease (PNAS 101, 6623-6628). Three-dimensional confocal imaging reveals extensive vacuoles caused by neurodegeneration in the brain of aged but not young A β 42 flies. Here, we report a three-dimensional computation algorism allowing semi-automatic measurement of numbers and volumes of brain vacuoles. The method employed matched filters, α -shape, and the active-contour techniques. Using this method, a good result depicting the contours of the vacuoles can be obtained. A more accurate algorithm is still under development. Accurate evaluation of brain pathology in Alzheimer's flies may facilitate the understanding of molecular mechanisms underlying A β. toxicity and the discovery of novel therapeutic targets for Alzheimer's disease.

Original language	English
Title of host publication	Medical Imaging 2006
Subtitle of host publication	Physiology, Function, and Structure from Medical Images
DOIs	https://doi.org/10.1117/12.653069
State	Published - 30 Jun 2006
Event	Medical Imaging 2006: Physiology, Function, and Structure from Medical Images - San Diego, CA, United States Duration: 12 Feb 2006 → 14 Feb 2006

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	6143 II
ISSN (Print)	1605-7422

Conference

Conference	Medical Imaging 2006: Physiology, Function, and Structure from Medical Images
Country	United States
City	San Diego, CA
Period	12/02/06 → 14/02/06

Keywords

α-Shape
Active-contour
Confocal microscopic images
Matched filter
Snake

Access to Document

10.1117/12.653069

Link to publication in Scopus

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title = "Computation of brain neurodegeneration in the Alzheimer's fly",

abstract = "Expression of human A/342 peptide in the Drosophila brain induces pathological phenotypes resembling Alzheimer's disease (PNAS 101, 6623-6628). Three-dimensional confocal imaging reveals extensive vacuoles caused by neurodegeneration in the brain of aged but not young A β 42 flies. Here, we report a three-dimensional computation algorism allowing semi-automatic measurement of numbers and volumes of brain vacuoles. The method employed matched filters, α -shape, and the active-contour techniques. Using this method, a good result depicting the contours of the vacuoles can be obtained. A more accurate algorithm is still under development. Accurate evaluation of brain pathology in Alzheimer's flies may facilitate the understanding of molecular mechanisms underlying A β. toxicity and the discovery of novel therapeutic targets for Alzheimer's disease.",

keywords = "α-Shape, Active-contour, Confocal microscopic images, Matched filter, Snake",

author = "Lee, {P. C.} and Huang, {Y. R.} and Chang, {H. M.} and Chiang, {A. S.} and Yu-Tai Ching",

year = "2006",

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day = "30",

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language = "English",

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series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

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note = "null ; Conference date: 12-02-2006 Through 14-02-2006",

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Lee, PC, Huang, YR, Chang, HM, Chiang, AS & Ching, Y-T 2006, Computation of brain neurodegeneration in the Alzheimer's fly. in Medical Imaging 2006: Physiology, Function, and Structure from Medical Images., 61433E, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 6143 II, Medical Imaging 2006: Physiology, Function, and Structure from Medical Images, San Diego, CA, United States, 12/02/06. https://doi.org/10.1117/12.653069

Computation of brain neurodegeneration in the Alzheimer's fly. / Lee, P. C.; Huang, Y. R.; Chang, H. M.; Chiang, A. S.; Ching, Yu-Tai.

Medical Imaging 2006: Physiology, Function, and Structure from Medical Images. 2006. 61433E (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6143 II).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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