@inproceedings{1b05396029b7425a821032a88069b8bd,
title = "Computation of brain neurodegeneration in the Alzheimer's fly",
abstract = "Expression of human A/342 peptide in the Drosophila brain induces pathological phenotypes resembling Alzheimer's disease (PNAS 101, 6623-6628). Three-dimensional confocal imaging reveals extensive vacuoles caused by neurodegeneration in the brain of aged but not young A β 42 flies. Here, we report a three-dimensional computation algorism allowing semi-automatic measurement of numbers and volumes of brain vacuoles. The method employed matched filters, α -shape, and the active-contour techniques. Using this method, a good result depicting the contours of the vacuoles can be obtained. A more accurate algorithm is still under development. Accurate evaluation of brain pathology in Alzheimer's flies may facilitate the understanding of molecular mechanisms underlying A β. toxicity and the discovery of novel therapeutic targets for Alzheimer's disease.",
keywords = "α-Shape, Active-contour, Confocal microscopic images, Matched filter, Snake",
author = "Lee, {P. C.} and Huang, {Y. R.} and Chang, {H. M.} and Chiang, {A. S.} and Yu-Tai Ching",
year = "2006",
month = jun,
day = "30",
doi = "10.1117/12.653069",
language = "English",
isbn = "0819461865",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Medical Imaging 2006",
note = "null ; Conference date: 12-02-2006 Through 14-02-2006",
}