Comparison of Gd-Bz-TTDA, Gd-EOB-DTPA, and Gd-BOPTA for dynamic MR imaging of the liver in rat models

Twei Shiun Jaw*, Shih Hsien Chen, Yun-Ming Wang, Jui Sheng Hsu, Yu Ting Kuo, Yen Yu Chiu, Kun Bow Tsai, Tsyh Jyi Hsieh, Gin Chung Liu

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

To evaluate the competitive potential of a new lipophilic paramagnetic complex, Gd-Bz-TTDA [4-benzyl-3,6,10-tri (carboxymethyl)-3,6,10-triazado- decanedioic acid] compared with two other commercially available MR hepatobiliary contrast agents, gadobenate dimeglumine (Gd-BOPTA) and gadoxetic acid (Gd-EOB-DTPA), dynamic MR imaging studies were performed on normal and hepatocellular carcinoma (HCC) rat models using a 1.5-Tesla MR scanner. The results indicate that normal rats that were injected with 0.1 mmol/kg Gd-Bz-TTDA showed significantly more intense and persistent liver enhancement than those that were injected with the same dose of Gd-EOB-DTPA or Gd-BOPTA. All of these agents showed similar enhancement patterns in the implanted HCC. The liver-lesion contrast-to-noise ratios were higher and more persistent in rats that were injected with Gd-Bz-TTDA. These results indicate that Gd-Bz-TTDA is comparable with the commercially available hepatobiliary agents, Gd-EOB-DTPA and Gd-BOPTA, and can result in more intense and prolonged liver enhancement while still providing better liver-lesion discrimination. These results warrant further large-scale studies.

Original languageEnglish
Pages (from-to)130-137
Number of pages8
JournalKaohsiung Journal of Medical Sciences
Volume28
Issue number3
DOIs
StatePublished - 1 Mar 2012

Keywords

  • Contrast agents
  • Hepatobiliary
  • Magnetic resonance imaging

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