CMOS phototransistor device: A total solution for skin whitening assays

Yen Pei Lui*, Yu Wei Chang, Ming Yu Lin, Jiann Shiun Kao, Yang Tung Huang, Yuh-Shyong Yang

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

Three skin whitening assays combining the semiconductor technology was demonstrated for screening the drug candidate and discussing the mechanisms of melanogenesis in medical cosmetics. We proposed a miniaturized photometric system using complementary metal oxide semiconductor (CMOS) phototransistor as a detector with high sensitivity. The CMOS phototransistor was a small, portable optoelectronic device with enlarged depletion region of the outer N well/Pwell ring-shaped photodiode, able to cause a sensitive shift of the threshold voltage and enhance photocurrent response. The device was further connected to IC system to show it ability for high-throughput screening needed in the pharmaceutical industry. Three methods for evaluating effects of skin whitening agent were applied, including 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazoliu m bromide (MTT) assay, melanin amount measurement, and tyrosinase assays. The change of light absorbance due to enzymeatic catalysis was easily measured with the proposed system. The skin whitening effects by kojic acid was determined and comparable to the commercial system.

Original languageEnglish
Title of host publication2009 IEEE 3rd International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2009
Pages154-157
Number of pages4
DOIs
StatePublished - 1 Dec 2009
Event2009 IEEE 3rd International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2009 - Tainan, Taiwan
Duration: 18 Oct 200921 Oct 2009

Publication series

Name2009 IEEE 3rd International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2009

Conference

Conference2009 IEEE 3rd International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2009
CountryTaiwan
CityTainan
Period18/10/0921/10/09

Keywords

  • CMOS phototransistor
  • Kojic acid
  • Melanin
  • Melanogenesis
  • Tyrosinase

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