cIAP-2 Expression Increases in Elderly Patients with Squamous Cell Carcinoma of the Head and Neck

Chi Long Chen, Chun Yi Chiang, Kuang-Wen Liao, Shu Yi Ho, Yi Fang Chang, Ken Hong Lim, Ruey Kuen Hsieh, Yu Ling Lin, Ying Wen Su*

*Corresponding author for this work

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1 Scopus citations

Abstract

Background Evidence indicates apoptosis deregulation is associated with aging. We correlated expression of cIAP-2, a member of the inhibitor of apoptosis protein family, with survival and age in patients with resected squamous cell carcinoma of head and neck (SCCHN). Methods Immunohistochemical (IHC) staining for cIAP-2 and other markers were performed using tissue microarrays from 103 resected SCCHN patients. Expression was grouped according to IHC scores (0–3) and statistical association with clinical–pathological factors was determined. Results High expression of cIAP-2 was found to be increased in patients aged 60 or greater. High expression of cIAP-2 and an age ≥60 were significantly associated with worse survival in univariate analysis, but only an age ≥60, and not cIAP-2 expression, was prognostic in multivariate analysis. Conclusion High expression of cIAP-2 was found more frequently in elderly SCCHN patients but was not independently associated with survival after adjusting other clinical–pathologic factors.

Original languageEnglish
Pages (from-to)22-26
Number of pages5
JournalInternational Journal of Gerontology
Volume11
Issue number1
DOIs
StatePublished - 1 Mar 2017

Keywords

  • cIAP-2
  • squamous cell carcinoma of head and neck

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    Chen, C. L., Chiang, C. Y., Liao, K-W., Ho, S. Y., Chang, Y. F., Lim, K. H., Hsieh, R. K., Lin, Y. L., & Su, Y. W. (2017). cIAP-2 Expression Increases in Elderly Patients with Squamous Cell Carcinoma of the Head and Neck. International Journal of Gerontology, 11(1), 22-26. https://doi.org/10.1016/j.ijge.2016.04.003