Chiral liquid crystals as biosensing platforms

Mon Juan Lee, Yu Chien Sung, Yu Cheng Hsiao, Wei Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations


The texture observation has long been the core technique in liquid crystal (LC)-based bioassays. Its working principle stems from the dark-to-bright texture change induced by the interruption of the initially homeotropic alignment in nematic bulks or from the radial-to-bipolar configuration transition in LC droplets in the presence of biomolecules. One of the drawbacks of this observational scheme, which requires a polarizing optical microscope, is the difficulty in quantitative analysis. In this invited paper, we report on our recent development of alternative optical biosensing techniques based on cholesteric LCs (CLCs) without the use of a polarizer. The increase in structural order in a vertically anchored CLC cell in the quasi-planar state provides a means to allow detection and quantification of the concentration of biomolecules immobilized on the interface between the mesophase and the surfactant DMOAP for LC vertical alignment.

Original languageEnglish
Title of host publicationLiquid Crystals XX
EditorsIam Choon Khoo
ISBN (Electronic)9781510602717
StatePublished - 1 Jan 2016
EventLiquid Crystals XX - San Diego, United States
Duration: 28 Aug 201630 Aug 2016

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X


ConferenceLiquid Crystals XX
CountryUnited States
CitySan Diego


  • Biophotonics
  • Biosensors
  • Cholesteric liquid crystals
  • Liquid crystals
  • Transmission spectroscopy

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