Chemistry of ketone α,β-dianions. Acylation reactions of dianion cuprates by acid chlorides

Ilhyong Ryu*, Masanobu Ikebe, Noboru Sonoda, Shin Ya Yamato, Go Hei Yamamura, Mitsuo Komatsu

*Corresponding author for this work

Research output: Contribution to journalArticle

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Abstract

The cross-coupling reaction of dianion cuprates, generated from ketone α,β-dianions and copper salts, with acid chlorides, was studied. The reaction gave good to moderate yields of unsymmetrical 1,4-diketones. The consecutive treatment of a dianion cuprate with cyclohexanecarbonyl chloride and methyl iodide or two different acid chlorides gave 2-methyl-substituted 1,4-diketone or triketone, respectively.

Original languageEnglish
Pages (from-to)1257-1259
Number of pages3
JournalTetrahedron Letters
Volume43
Issue number7
DOIs
StatePublished - 11 Feb 2002

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