Chemical Production from Methanol Using Natural and Synthetic Methylotrophs

Arvin Y. Chen, Ethan I. Lan*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Methanol as a chemical feedstock is becoming increasingly important as it is derived from natural gas and is a feasible end-product for captured carbon dioxide. Biological conversion of methanol through natural and synthetic methylotrophs increases the chemical repertoire and is an important direction for one carbon (C1) based chemical economy. Advances in the metabolic engineering and synthetic biology enable development of microbial cell factories for converting methanol into various platform chemicals. In this review, the current status of methanol utilizing microbial factory development is summarized. Also the development of synthetic methylotrophy and methanol-augmented bioproductions is discussed.

Original languageEnglish
Article number1900356
Number of pages14
JournalBiotechnology Journal
DOIs
StateAccepted/In press - Apr 2020

Keywords

  • METHYLOBACTERIUM-EXTORQUENS AM1
  • L-LYSINE PRODUCTION
  • L-SERINE PRODUCTION
  • BACILLUS-METHANOLICUS
  • METHYLOPHILUS-METHYLOTROPHUS
  • OBLIGATE METHYLOTROPH
  • BIOLOGICAL CONVERSION
  • BIOSYNTHETIC-PATHWAY
  • ACID PRODUCTION
  • RESTING CELLS

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