TY - JOUR
T1 - Characterization of mdcR, a regulatory gene of the malonate catabolic system in Klebsiella pneumoniae
AU - Peng, Hwei-Ling
AU - Shiou, Sheng Ru
AU - Chang, Hwan You
PY - 1999/4/1
Y1 - 1999/4/1
N2 - The Klebsiella pneumoniae mdcR gene, which encodes a LysR-type regulator, was overexpressed in Escherichia coli. Purified MdcR was found to bind specifically to the control region of either the malonate decarboxylase (mdc) genes or mdcR. We have also demonstrated that MdcR is an activator of the expression of the mdc genes, whereas it represses the transcription of the putative control region of mdcR, P(mdcR), indicating a negative autoregulatory control.
AB - The Klebsiella pneumoniae mdcR gene, which encodes a LysR-type regulator, was overexpressed in Escherichia coli. Purified MdcR was found to bind specifically to the control region of either the malonate decarboxylase (mdc) genes or mdcR. We have also demonstrated that MdcR is an activator of the expression of the mdc genes, whereas it represses the transcription of the putative control region of mdcR, P(mdcR), indicating a negative autoregulatory control.
UR - http://www.scopus.com/inward/record.url?scp=0032936314&partnerID=8YFLogxK
U2 - 10.1128/JB.181.7.2302-2306.1999
DO - 10.1128/JB.181.7.2302-2306.1999
M3 - Article
C2 - 10094715
AN - SCOPUS:0032936314
VL - 181
SP - 2302
EP - 2306
JO - Journal of Bacteriology
JF - Journal of Bacteriology
SN - 0021-9193
IS - 7
ER -