Characterization of mdcR, a regulatory gene of the malonate catabolic system in Klebsiella pneumoniae

Hwei-Ling Peng, Sheng Ru Shiou, Hwan You Chang*

*Corresponding author for this work

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The Klebsiella pneumoniae mdcR gene, which encodes a LysR-type regulator, was overexpressed in Escherichia coli. Purified MdcR was found to bind specifically to the control region of either the malonate decarboxylase (mdc) genes or mdcR. We have also demonstrated that MdcR is an activator of the expression of the mdc genes, whereas it represses the transcription of the putative control region of mdcR, P(mdcR), indicating a negative autoregulatory control.

Original languageEnglish
Pages (from-to)2302-2306
Number of pages5
JournalJournal of Bacteriology
Volume181
Issue number7
DOIs
StatePublished - 1 Apr 1999

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