Cascade carbonylation methods leading to β-diketones and β-functionalized δ-diketones

Katsukiyo Miura, Mami Tojino, Naoki Fujisawa, Akira Hosomi*, Ilhyong Ryu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

A radical combination: An intermolecular cascade reaction involving alkyl halides, CO, electron-deficient alkenes, and stannyl enolates proceeds smoothly by a radical chain pathway to give four-component coupling products in good to high yields (see scheme). A series of 1,5-diketones with a substituent at the 3-position was prepared by this method.

Original languageEnglish
Pages (from-to)2423-2425
Number of pages3
JournalAngewandte Chemie - International Edition
Volume43
Issue number18
DOIs
StatePublished - 26 Apr 2004

Keywords

  • Carbonylation
  • Enolates
  • Ketones
  • Multicomponent reactions
  • Tin

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