Cadherin and catenin expression in mucoepidermoid carcinoma: Correlation with histopathologic grade, clinical stage, and patient outcome

Yi Shing Shieh, Long Chang Chang, Kuo Chou Chiu, Cheng-Wen Wu, Herng Sheng Lee*

*Corresponding author for this work

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Background: Alteration of cadherin and catenin expression is associated with loss of differentiation, acquisition of an invasive phenotype, and poor prognosis in many types of cancers. The roles of cadherins and catenins in mucoepidermoid carcinoma (MEC) are not fully understood. Methods: Based on immunohistochemical studies, the expressions of E-, N-, and P-cadherins and α, β, and γ-catenins in MEC were investigated, and correlations with clinicopathologic parameters were evaluated. Results: These six molecules were strongly expressed in normal ductal epithelium but increased or decreased immunoreactivities of those proteins in MEC were frequently observed, especially for E-cadherin and α-catenin. The immunoactivity of β-catenin showed significant correlation with grade (P=0.05) and stage (P<0.0001). β-Catenin expressions are also correlated with γ-catenin expression (P=0.006) according to cross-table analysis. Survival analysis indicated that stage, grade, and β-catenin expressions had significant correlation with survival. Conclusion: Aberrant β-catenin expression may play an important role in the histologic differentiation and tumor staging of MEC.

Original languageEnglish
Pages (from-to)297-304
Number of pages8
JournalJournal of Oral Pathology and Medicine
Volume32
Issue number5
DOIs
StatePublished - 1 Jan 2003

Keywords

  • Cadherin
  • Catenin
  • Mucoepidermoid carcinoma

Fingerprint Dive into the research topics of 'Cadherin and catenin expression in mucoepidermoid carcinoma: Correlation with histopathologic grade, clinical stage, and patient outcome'. Together they form a unique fingerprint.

  • Cite this