Biomedical nanoparticle carriers with combined thermal and magnetic responses

Ting Yu Liu, Shang Hsiu Hu, Dean-Mo Liu, San-Yuan Chen, I. Wei Chen*

*Corresponding author for this work

Research output: Contribution to journalReview article

238 Scopus citations

Abstract

Several biocompatible polymers are capable of large responses to small temperature changes around 37 °C. In water, their responses include shrinkage and swelling as well as transitions in wettability. These properties have been harnessed for biomedical applications such as tissue engineering scaffolds and drug delivery carriers. A soft material/hard material hybrid in which a magnetic metal or oxide is embedded in a temperature-responsive polymer matrix can combine the thermal sensitivity with magnetic signatures. Importantly, nanosizing such construct brings about new desirable features of extremely fast thermal response time, small magnetic hysteresis and enhanced magnetic susceptibility. Remote magnetic maneuvering and heating of the hybrid nanocolloids makes possible such applications as high-throughput enzyme separation and cell screening. Robust drug release on demand may also be obtained using these colloids and nanoparticle-derived thin film devices of combined thermal magnetic sensitivity.

Original languageEnglish
Pages (from-to)52-65
Number of pages14
JournalNano Today
Volume4
Issue number1
DOIs
StatePublished - 1 Feb 2009

Keywords

  • Biomedical
  • Drug delivery
  • Magnetic response
  • Nanoparticles
  • Thermal response

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