To deal with the complex and huge amount of biological information, more efficient instruments are needed in this post-genomic era for medical diagnosis, curing diseases, prevention of terrorist acts, and many other bioanalytical problems. The development of semiconductor sensors and integrated circuit for biochemical diagnosis may be the answer for an accurate, portable, relatively inexpensive, and easy-to-use biosensing device. A complementary metal oxide semiconductor manufactured through a standard industrial process for biochemical sensing has been successfully designed. The biochemical signals were further magnified and analyzed by an integrated circuit. The design of a portable system was proposed, which may become a convenient diagnostic kit on the go. Finally, a functional system that uses commercially available photodiode and other electronic devices was assembled. The set up provides a test platform that can be used as a model for an integrated system for the IC design in a semiconductor chip.