Baculovirus as a gene delivery vector: Recent understandings of molecular alterations in transduced cells and latest applications

Chi Yuan Chen, Chin Yu Lin, Guan-Yu Chen, Yu Chen Hu*

*Corresponding author for this work

Research output: Contribution to journalReview article

93 Scopus citations

Abstract

Baculovirus infects insects in nature and is non-pathogenic to humans, but can transduce a broad range of mammalian and avian cells. Thanks to the biosafety, large cloning capacity, low cytotoxicity and non-replication nature in the transduced cells as well as the ease of manipulation and production, baculovirus has gained explosive popularity as a gene delivery vector for a wide variety of applications. This article extensively reviews the recent understandings of the molecular mechanisms pertinent to baculovirus entry and cellular responses, and covers the latest advances in the vector improvements and applications, with special emphasis on antiviral therapy, cancer therapy, regenerative medicine and vaccine.

Original languageEnglish
Pages (from-to)618-631
Number of pages14
JournalBiotechnology Advances
Volume29
Issue number6
DOIs
StatePublished - 1 Nov 2011

Keywords

  • Antiviral therapy
  • Baculovirus
  • Cancer therapy
  • Immune responses
  • Tissue engineering
  • Vaccine

Fingerprint Dive into the research topics of 'Baculovirus as a gene delivery vector: Recent understandings of molecular alterations in transduced cells and latest applications'. Together they form a unique fingerprint.

  • Cite this