Autonomic nerve activity and the short-term variability of the T peak-Tend interval in dogs with pacing-induced heart failure

Gianfranco Piccirillo*, Damiano Magrì, Maria A. Pappadà, Antonello Maruotti, Masahiro Ogawa, Seongwook Han, Boyoung Joung, Pietro Rossi, Bich Lien Nguyen, Shien-Fong Lin, Peng Sheng Chen

*Corresponding author for this work

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

BACKGROUND: In congestive heart failure (CHF), autonomic nervous system (ANS) activity is known to modulate arrhythmic risk through its effects on myocardial repolarization. An increased interval between the peak and the end of the T wave (Tpeak-Tend) has been reported to increase the incidence of sudden cardiac death. However, the ANS influence on the T peak-Tend interval remains unclear. OBJECTIVE: We directly measured ANS nerve activity in ambulatory dogs with pacing-induced CHF to test the hypothesis that ANS activity modulates the Tpeak-Tend variability index (Tpeak-TendVI), the short-term variability of the Tpeak-Tend interval obtained on 30 beats (Tpeak-TendSTV30), and the short-term variability of the Tpeak-Tend interval obtained on 5-minute ECG recording (Tpeak-TendSTVT). METHODS: By using data previously recorded in 6 ambulatory dogs before and after pacing-induced CHF, we assessed ANS activity recorded with an implanted radiotransmitter that monitored integrated left stellate ganglion nervous activity (iSGNA), integrated vagus nerve activity (iVNA), and electrocardiogram (ECG). We selected for analysis 36 segments recorded at baseline and 36 after pacing-induced CHF with similar iSGNA. RESULTS: During CHF, T peak-TendSTV30 (P<.001) and T peak-TendSTVT (P<.05) were significantly higher than those at baseline. The multiple linear mixed regression analysis disclosed a significant positive correlation between iSGNA and T peak-TendSTVT (baseline: β 2.92, P<.001; CHF: β 1.13, P<.001) and a significant negative correlation between iVNA and Tpeak-TendSTVT (baseline: β-6.74, P<.001; CHF: β-1.42, P<.001). CONCLUSIONS: In a canine model of pacing-induced CHF, iSGNA correlates positively while iVNA correlates negatively with Tpeak-TendSTVT. These findings suggest that SGNA increases while VNA decreases the dispersion of ventricular repolarization in ambulatory dogs with CHF.

Original languageEnglish
Pages (from-to)2044-2050
Number of pages7
JournalHeart Rhythm
Volume9
Issue number12
DOIs
StatePublished - 1 Dec 2012

Keywords

  • Autonomic nervous system
  • Chronic heart failure
  • QT variability
  • Sudden cardiac death

Fingerprint Dive into the research topics of 'Autonomic nerve activity and the short-term variability of the T <sub>peak</sub>-T<sub>end</sub> interval in dogs with pacing-induced heart failure'. Together they form a unique fingerprint.

  • Cite this

    Piccirillo, G., Magrì, D., Pappadà, M. A., Maruotti, A., Ogawa, M., Han, S., Joung, B., Rossi, P., Nguyen, B. L., Lin, S-F., & Chen, P. S. (2012). Autonomic nerve activity and the short-term variability of the T peak-Tend interval in dogs with pacing-induced heart failure. Heart Rhythm, 9(12), 2044-2050. https://doi.org/10.1016/j.hrthm.2012.08.030