Au-Ag core-shell nanoparticles with controllable shell thicknesses for the detection of adenosine by surface enhanced Raman scattering

Fu-Hsiang Ko, Ming Rou Tai, Fu Ken Liu, Yu Cheng Chang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

In this study, we report a feasible aqueous chemical method to synthesize Au core-Ag shell nanoparticles (NPs) by seeding growth approach. The concentration of Au NPs plays an important role in growing the different thicknesses of Ag shells. The design of signaling aptamer utilizes the target-induced switching between an aptamer/DNA duplex and an aptamer/target complex. The surface enhanced Raman scattering (SERS) signal was enhanced upon the hybridization of the Raman reporter-labeled DNA released from the target-induced displacement with the captured DNA immobilized on the silicon substrate with Au-Ag core-shell NPs. This substrate with 12.4 nm Ag shell shows high reproducibility, strong enhancement, and a low detection limit (1 nM). The enhancement in DNA-based adenosine detection properties shall be advantageous in applications for other aptamer sensing systems.

Original languageEnglish
Pages (from-to)283-289
Number of pages7
JournalSensors and Actuators, B: Chemical
Volume211
DOIs
StatePublished - 1 Jan 2015

Keywords

  • Adenosine
  • Aptamer
  • Nanoparticles
  • Raman scattering
  • Seeding growth
  • Surface enhanced

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